The MAOIs are infamous for their numerous drug interactions, including the following kinds of substances: Substances that are metabolized by monoamine oxidase, as they can be boosted by up to several-fold. Paxil is a psychotropic drug (specifically an SSRI, or selective seritonin re-uptake inhibitor). Used for treating depression, panic disorders and OCD, it works on the assumption that other. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine. After you stop taking Paxil you must wait at least 14 days before you start taking an MAO inhibitor. Monoamine oxidase inhibitors (MAOIs) – Taking Paxil with MAOI drug can lead to life-threatening side effects. Paxil should never be taken with MAOI drugs. If you have taken a MAOI drug, wait for at least two weeks before you start Paxil. A: Paxil and Prozac are both SSRIs and neither are significant MAOIs. We have consistent reports from those who use Paxil and Prozac on a daily basis who say that the effects of MDMA are reduced (from slightly lessened to completely nullified) when it is taken while on either of these anti-depressants. Paxil was first approved by the U.S. Food an Drug Administration (FDA) in 1992. Since the patent expiry in 2002, the drug is now available as a low-cost generic. Consequently, patients should be evaluated carefully for history of drug abuse, and such patients should be observed closely for signs of misuse or abuse of PAXIL (e.g., development of tolerance, incrementations of dose, drug-seeking behavior). They include Celexa, Lexapro, Luvox, Paxil, Prozac, and Zoloft. Another drug, Symbyax , is approved by the FDA specifically for treatment-resistant depression. Paxil (paroxetine hydrochloride) is a selective serotonin reuptake inhibitor antidepressant used to treat depression, panic attacks, obsessive-compulsive disorder , anxiety disorders, post-traumatic stress disorder, and a severe form of premenstrual syndrome (premenstrual dysphoric disorder). Paxil does not contain an MAOI. Paxil is an SSRI, which is a safer group of antidepressants. However, please double check this with a pharmacist, take care.